Kisspeptin-10 is a synthetic 10-amino acid peptide corresponding to the C-terminal decapeptide fragment of kisspeptin (metastin), a 54-amino acid hypothalamic neuropeptide encoded by the KISS1 gene. CAS 374683-17-7, molecular formula C₆₃H₈₃N₁₅O₁₂, molecular weight 1302.55 g/mol. The C-terminal region is essential for binding to the kisspeptin receptor (KISS1R, formerly GPR54).
Kisspeptin-10 is the biologically active minimal fragment of kisspeptin and acts as a potent KISS1R agonist. It plays a central role in the regulation of the hypothalamic-pituitary-gonadal (HPG) axis and is considered a master regulator of GnRH neuron activity in research models. Research applications include studies of GnRH pulse generation, LH and FSH secretion dynamics, KISS1R signaling pathways, and the neuroendocrine regulation of puberty and reproductive function.
Supplied as a lyophilized powder. Each lot is independently tested by HPLC-UV with a minimum purity threshold of ≥99.0%. Molecular identity confirmed by LC-MS prior to release. Certificate of Analysis available for every lot number.
For laboratory and in-vitro research use only. Not for human or veterinary use. Not FDA approved.