Sermorelin is a synthetic peptide corresponding to the biologically active N-terminal 29-amino acid fragment of endogenous human growth hormone-releasing hormone (hGHRH 1-29-NH₂). CAS 86168-78-7, molecular formula C₁₄₉H₂₄₆N₄₄O₄₂S, molecular weight 3357.88 g/mol. The C-terminal amide group is essential for GHRH receptor binding affinity and is preserved in this compound.
Sermorelin is the shortest GHRH fragment demonstrated to retain full receptor binding and biological activity in research models, making it a widely used tool compound in GH axis studies. Research applications include the characterization of GHRH receptor structure-activity relationships, pituitary somatotroph cell biology, and the investigation of GH secretion dynamics. It has also been employed as a reference comparator in studies examining GHRH analog pharmacology.
Supplied as a lyophilized powder. Each lot is independently tested by HPLC-UV at 218nm with a minimum purity threshold of ≥99.0%. Molecular identity confirmed by LC-MS prior to release. Certificate of Analysis available for every lot number.
For laboratory and in-vitro research use only. Not for human or veterinary use. Not FDA approved.